📡 OpenDoor Soars 100%

+ Sarepta Stock Crashes After FDA Probe and $0 Price Target Over Gene Therapy Deaths

July 21, 2025

In partnership with

Good afternoon! Austin’s about to get its own underground delivery highway. Pipedream Labs just launched a 40-mile tunnel system that uses 100mph autonomous bots to deliver anything (tacos, tools, toothpaste) to local pickup points called Portals in under 15 minutes. Delivery costs? As low as 25 cents.

It’s not sci-fi. The system is already live in Austin, with plans to expand fast. Pipedream’s long-term vision is to make physical goods as instantly accessible as digital ones—turning homes and apartments into download points for groceries, gadgets, and returns.

MARKETS

*Stock data as of market close*

  • The S&P 500 closed above 6,300 for the first time ever on Monday, rising 0.14%, while the Nasdaq jumped 0.38% to notch its sixth straight record close. Gains in tech giants like Meta and Amazon helped push both indexes to new intraday highs, as traders geared up for a packed week of earnings.

  • The Dow didn’t join the party, slipping 19 points to end just below flat. But for now, investor focus is firmly on Big Tech results rather than tariff drama, with markets showing resilience even as trade tensions simmer in the background.

TV Ads That Perform Like Digital

We have entered a new era of TV advertising where the barriers to entry are lower than ever, and Roku Ads Manager is leading the way.

Growth marketers can access Roku’s audience reach in the US with a self-service ad platform that’s built for performance.

Roku powers 47% of all TV streaming time in the US*, so your brand can run ads alongside premium content and meet your audience where they’re already engaged. *Comscore, 2024

STOCKS
Winners & Losers

What’s up 📈

  • Opendoor Technologies exploded 42.67% as meme stock mania continued, adding to last week’s 188% surge. ($OPEN)

  • Cleveland-Cliffs soared 12.45% after announcing lower-than-expected capital and administrative expenses for the year, offsetting a wider Q2 loss. ($CLF)

  • Block jumped 7.22% after being named to replace Hess in the S&P 500 before markets open on July 23. ($XYZ)

  • SolarEdge rose 8.30% after Susquehanna raised its price target to $26, despite broader sector headwinds from the Trump administration’s push to end federal support. ($SEDG)

  • Verizon gained 4.04% after beating Q2 earnings and revenue estimates. ($VZ)

  • Pinterest added more than 2.40% following an upgrade to overweight at Morgan Stanley, which cited attractive valuation and monetization improvements. ($PINS)

  • Dollar Tree climbed 2% after Barclays upgraded the stock to overweight, seeing a “cleaner growth story” ahead. ($DLTR)

What’s down 📉

  • Bruker dropped 12.12% after issuing disappointing preliminary Q2 earnings, well below analyst expectations. ($BRKR)

  • Arrowhead Pharmaceuticals fell nearly 12.23%, continuing a multi-day slide following Sarepta-related biotech weakness. ($ARWR)

  • Alkermes declined 8.76% after Phase 2 trial results for its narcolepsy drug alixorexton failed to impress. ($ALKS)

  • EQT Corporation sank 9.55% after its CEO warned that China could win the AI race unless permitting for U.S. energy projects is streamlined. ($EQT)

  • Sarepta Therapeutics dropped another 5.36% after the FDA pulled support for its Elevidys gene therapy due to another patient death. ($SRPT)

MEME
Opendoor Stock Soars 100% in Meme Rally as Gamma Squeeze, Call Volume, and FOMO Drive Surge

Opendoor Technologies just entered full meme mode. Shares surged more than 60% on Monday, pushing past $4 and marking a 100%+ gain in the last week. The fuel? A perfect cocktail of momentum chasing, meme stock FOMO, and one of the wildest gamma squeezes in recent memory. Call option volume topped 1 million for the first time ever — yes, ever — with buyers piling into contracts that didn’t even exist on the radar a day prior.

Trading Like It’s 2021 Again

The price action has all the hallmarks of GameStop 2.0. An influential investor hyped the stock on X, triggering a frenzy that sent shares flying. Despite being a shell of its 2021 self (when it was worth $20.6B), Opendoor now boasts a $3.2B market cap and more than 1 billion shares traded in a single day. Meanwhile, trading volumes and call buying have shattered records five days in a row.

But Fundamentals Still Matter

Unlike GameStop’s existential pivot under Ryan Cohen, Opendoor is still grinding in the tough real estate sector. Its iBuyer business model, designed to buy and flip homes at speed — has been bruised by a frozen housing market. Existing home sales are down 50% since 2020. Mortgage rates above 6.8% have sellers locked in and buyers hesitant, with a majority of Americans saying they wouldn’t make a move right now.

Short Sellers Smell Opportunity
With shares mooning, short sellers are re-entering the chat. As bets against the company increase, Opendoor could see even more volatile swings in either direction. Gamma squeezes don’t last forever, and Wall Street’s pros are already betting the ride ends with a thud.

The Bottom Line: Opendoor’s move may be historic, but it’s not guaranteed to be sustainable. What we’re watching now is pure sentiment, call options, social buzz, and a race to catch a rocket mid-flight. Whether it ends like GameStop or fades like Bed Bath & Beyond, one thing’s for sure: this door’s wide open…for chaos.

NEWS
Market Movements

STOCK
Sarepta Stock Crashes After FDA Probe and $0 Price Target Over Gene Therapy Deaths

Sarepta Therapeutics is crashing headfirst into biotech infamy. Once a rising star in gene therapy with its flagship drug Elevidys, the company is now the subject of a rare $0 price target from HC Wainwright. Analysts say its clash with the FDA is “unwinnable” and expect the regulator to force Elevidys off the market. That would effectively gut the company’s revenue and erase any remaining value for shareholders.

Three Deaths, Zero Confidence: The FDA’s concerns stem from three patient deaths tied to Sarepta’s gene therapies—two teens with Duchenne muscular dystrophy and one adult in a separate trial. Sarepta’s refusal to voluntarily halt shipments of Elevidys has only intensified scrutiny. Critics argue the company is clinging to the drug not out of confidence in safety, but because Elevidys made up half of its revenue last quarter. That lifeline now looks more like a noose.

Layoffs, Disclosures, and a Crisis of Trust

To make matters worse, Sarepta failed to disclose the third death during a July restructuring call—an omission that some analysts called deceptive. The company laid off 500 employees and reshuffled its drug pipeline, a move that temporarily lifted the stock. But when news of the third fatality broke the next day, shares cratered 36%. A BMO investor survey found 85% of respondents now rate Sarepta leadership’s credibility at 2 or below on a 10-point scale.

Wall Street Pulls the Plug

The analyst exodus has been swift and severe. Just four months ago, 20 out of 23 analysts rated Sarepta a buy. Now, only 7 of 26 do. Deutsche Bank, Needham, and Leerink have all downgraded the stock to sell. Even bulls at JPMorgan admit that if Elevidys is pulled entirely—even for ambulatory patients—their investment thesis collapses.

Bottom Line: Sarepta’s fall is a stark reminder that in biotech, reputational damage can be as lethal as regulatory failure. With the FDA clamping down, analysts fleeing, and investors losing trust, Sarepta isn’t just on life support—it may already be brain-dead.

Calendar
On The Horizon

Tomorrow

Brace for a flood of earnings. Tuesday’s calendar is stacked with reports from defense giants like Lockheed Martin and RTX, homebuilder DR Horton, chipmaker Texas Instruments, and names across energy, finance, and consumer goods. From GM to Enphase to Sherwin Williams, it’s a full-spectrum pulse check on the economy.

Before Market Open:

  • Then there’s Coca-Cola, sliding into the spotlight before markets open. Last quarter, the soda king disappointed for the first time in 17 quarters, spooking shareholders with soft demand and cautious guidance. With inflation pinching and health trends rising, Wall Street’s watching to see if Coke can keep its fizz.

NEWS
The Daily Rundown

  • 🌀 Texas Flood Missing Count Revised: Texas officials revised the number of people missing from the Kerr County flooding down to three from an initial count of 97. The discrepancy came from confusion around unaccounted tourists, duplicated names, and search operations. Authorities continue recovery efforts after the catastrophic flash flooding, which destroyed hundreds of structures. The region is now under a burn ban as it assesses long-term damage.

  • ✈️ Delta Flight Avoids B-52 Bomber: A Delta regional flight operated by SkyWest had to make a sudden go-around near Minot, North Dakota, to avoid a collision with a B-52 bomber. The bomber appeared unexpectedly on approach, and the pilot took evasive action before safely landing. The FAA and SkyWest are investigating the incident, which raised concerns over civil-military air traffic coordination. No injuries occurred, but passengers described a tense moment.

  • 🏈 Trump Threatens Commanders Stadium Deal: Former President Trump said he may block the Washington Commanders’ $3.7 billion stadium plan unless the team restores its former “Redskins” name. He also called on the Cleveland Guardians to return to the “Indians” name in a broader push against team name changes. The Commanders' new stadium plan includes commercial development in D.C., with negotiations ongoing. Both teams have rejected the idea of reverting to their old names.

  • 🍔 In-N-Out Owner Moves HQ to Tennessee: In-N-Out Burger president Lynsi Snyder announced she is relocating the company’s headquarters from California to Tennessee. She cited concerns about rising crime, regulatory challenges, and wanting a better environment to raise her children. The company plans to open its Franklin, TN office in 2026 as part of a broader East Coast expansion. Its California headquarters will remain operational through 2030.

  • 🎖️ “Papa Jake” Larson Dies at 102: D-Day veteran and viral TikTok personality Jake “Papa Jake” Larson passed away at 102. He gained over a million followers for sharing stories of his service and life, bringing history to younger generations. Larson was awarded the Bronze Star and France’s Legion of Honor for his WWII contributions. His family said he was still cracking jokes until the very end.

  • 🥩 Beef Prices Hit Record Highs: The average price for beef steak in the U.S. hit a record $11.49 per pound, with ground beef jumping 12% to $6.12 per pound. A shrinking cattle supply — down 8% from 2019 — and years of drought have driven up prices. High feed costs and borrowing expenses have discouraged ranchers from rebuilding herds. Upcoming tariffs on Brazilian beef could push prices even higher.

  • 🛫 Alaska Airlines Grounds All Flights: Alaska Airlines temporarily grounded its entire fleet due to a computer network outage late Sunday night. The disruption lasted about three hours and affected planes from both Alaska and its Horizon Air unit. While the ground stop was lifted, the airline warned of continued delays and residual effects. The glitch comes a year after another major tech incident disrupted air travel.=

  • 🇯🇵 Japan PM Refuses to Resign After Election Loss: Japanese Prime Minister Shigeru Ishiba said he will stay in office despite his party losing its upper house majority in a recent election. He cited the need to combat inflation and complete a trade deal with the U.S. as key reasons for remaining. The loss leaves the LDP-led coalition in the minority in both houses. Ishiba emphasized political stability over resignation.

  • 🎤 Astronomer CEO Resigns After Kiss Cam Incident: Andy Byron, CEO of software startup Astronomer, resigned after being caught on a concert kiss cam with his Chief People Officer. The intimate moment, which went viral, triggered an internal investigation and left the CPO on leave. The incident quickly became an internet meme and led to board pressure for Byron to step down. The company is now managing leadership fallout.

  • 🏀 WNBA Players Demand Better Revenue Share: At the WNBA All-Star Game, players wore shirts reading “Pay Us What You Owe Us” to protest revenue-sharing disparities. WNBA players currently receive just 9.3% of league revenue compared to 50% for NBA players. The union wants a growth-based model tied to league profits instead of a fixed percentage. Commissioner Cathy Engelbert acknowledged the issue and said salary increases are on the horizon.

  • 📦 Return Fraud Cost U.S. Retailers $103B: Americans returned $685 billion worth of merchandise last year, but $103 billion of it was fraudulent. Fraudulent returns include worn clothes, empty boxes, and false delivery claims, mostly in e-commerce. Retailers are tightening return policies and stepping up fraud prevention efforts. The trend has become a costly challenge in the online retail economy

REFERRAL
Share Investinq 🤝 Acquire Swag

If you love reading our newsletter, don’t be selfish — share it. Odds are your favorite finance bro, trader, investor, or stock market fanatic will too.

Don’t keep all the market news to yourself — share the love using the unique link below.

We deliver you all the news for free every single day (go on… help us out ;)

And here’s the kicker: every referral you make gets you entered into a raffle to win some awesome prizes listed below. Just share the link below and you’ll be entered once they sign up.

RESOURCES
The Federal Reserve Resource

Join our small yet growing subreddit 🚀: https://www.reddit.com/r/investinq/

Wall Street Reads 💎 (Best Books):

Check out our latest issues 🎯: https://investinq.beehiiv.com